Further options for your experiments:
Application schemes and assay conditions can be adapted to your needs.
Whole-cell recordings or single-channel analysis in various expression systems
(HEK 293, CHO, Neuroblastoma etc.) can be conducted to test the effects of drugs on voltage-gated or ligand-gated ion channels.
B'SYS currently operates 4 automated patch clamp devices (Sophion Qpatch™).
Please contact us for details or offers → Contact
| Target | Gene | Species | Disorder | Manual | Automated | ||
|---|---|---|---|---|---|---|---|
| nAChR α3β4 | CHRNA3 / CHRNB4 | human | Cognition | 0 | 1 |  |
|
| nAChR α4β2 | CHRNA4 / CHRNB2 | human | Cognition | 0 | 0 |
|
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| nAChR α7 | CHRNA7 | human | Cognition / Psychiatric Disorders | 0 | 1 | |
| Target | Gene | Species | Disorder | Manual | Automated | ||
|---|---|---|---|---|---|---|---|
| GABAA α1β2γ2 | GABRA1 / GABRB2 / GABRG2 | human | Psychiatric Disorders | 0 | 0 |
|
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| GABAA α1β3γ2 | GABRA1 / GABRB3 / GABRG2 | human | 0 | 0 | |
||
| GABAA α2β2γ2 | GABRA2 / GABRB2 / GABRG2 | human | Psychiatric Disorders | 0 | 0 | |
|
| GABAA α3β2γ2 | GABRA3 / GABRB2 / GABRG2 | human | 0 | 0 | |
||
| GABAA α4β3δ | GABRA4 / GABRB3 / GABRD | human | Depression / Psychiatric Disorders | 0 | 1 | |
|
| GABAA α5β2γ2 | GABRA5 / GABRB2 / GABRG2 | human | Cognition | 0 | 0 | |
|
| GABAA α6β3δ | GABRA6 / GABRB3 / GABRD | human | Depression / Psychiatric Disorders | 0 | 1 | |
|
| GABAA (β3) | GABRB3 | human | 0 | 0 | |
| Target | Gene | Species | Disorder | Manual | Automated | ||
|---|---|---|---|---|---|---|---|
| AMPA | GRIA1 | human | Cognition / Psychiatric Disorders | 0 | 1 | |
|
| Kainate K1 | GRIK1 | human | Seizure disorders | 0 | 1 | |
|
| Kainate K2 | GRIK2 | human | Epilepsy | 0 | 0 | |
|
| Kainate K2 | GRIK2 | human | Epilepsy | 0 | 0 |
|
|
| Kainate K2/K5 | GRIK2 / GRIK5 | human | 0 | 1 | |
||
| NMDA (NR1 / 2A) | GRIN1 / GRIN2A | human | Epilepsy / Psychiatric Disorders | 0 | 0 |
|
|
| NMDA (NR1 / 2B) | GRIN1 / GRIN2B | human | Depression | 0 | 0 |
|
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| NMDA (NR1 / 2C) | GRIN1 / GRIN2C | human | 0 | 1 | |
||
| NMDA (NR1 / 2D) | GRIN1 / GRIN2D | human | Seizure disorders | 0 | 1 |
|
|
| Target | Gene | Species | Disorder | Manual | Automated | ||
|---|---|---|---|---|---|---|---|
| GlyRα1 | GLRA1 | human | Pain sensation | 0 | 0 |
|
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| GlyRα2 | GLRA2 | human | Epilepsy | 0 | 1 |
|
|
| GlyRα3 | GLRA3 | human | Pain sensation | 0 | 1 | |
|
| GlyRα3 | GLRA3 | rat | Pain sensation | 0 | 1 | |
|
| GlyRα3 | GLRA3 | human | Pain sensation | 0 | 0 |
|
|
| GlyRα3β | GLRA3 / GLRB | human | 0 | 1 | |
| Target | Gene | Species | Disorder | Manual | Automated | ||
|---|---|---|---|---|---|---|---|
| 5HT3A | 5HT3A | human | Psychiatric Disorders | 0 | 0 | |
|
| 5HT3A/B | 5HT3A / 5HT3B | human | 0 | 1 | |
| Target | Gene | Species | Disorder | Manual | Automated | ||
|---|---|---|---|---|---|---|---|
| ASIC1a long | ACCN2 | human | Pain | 0 | 0 | |
|
| ASIC1a short | ACCN2 | human | Pain | 0 | 0 | |
|
| ASIC1b | ACCN2 | human | Pain | 0 | 0 | |
|
| ASIC2 | ACCN1 | human | Epilepsy / Migraine / Pain | 0 | 1 | |
|
| ASIC3 | ACCN3 | human | Pain / Psoriasis | 0 | 1 | |
| Target | Gene | Species | Disorder | Manual | Automated | ||
|---|---|---|---|---|---|---|---|
| P2X1 | P2rx1 | human | Immune system related | 0 | 1 |
|
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| P2X2 | P2rx2 | human | 0 | 0 |
|
|
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| P2X2/3 | P2rx2/P2rx3 | human | Pain | 0 | 1 |
|
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| P2X3 | P2rx3 | human | Pain | 0 | 1 |
|
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| P2X4 | P2rx4 | human | Immune system related | 0 | 0 |
|
|
| P2X7 | P2rx7 | human | Neuroinflammation | 0 | 0 |
|
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