Ion channel screening | B′SYS is equipped with state of the art patch-clamp technology. Our setups are equipped with systems for rapid drug application. Ion channel screening | B′SYS is equipped with state of the art patch-clamp technology. Our setups are equipped with systems for rapid drug application. Ion channel screening | B′SYS is equipped with state of the art patch-clamp technology. Our setups are equipped with systems for rapid drug application.
GLP testing | B′SYS specially trained study directors provide guideline compliantGLP testing | B′SYS specially trained study directors provide guideline compliantGLP testing | B′SYS specially trained study directors provide guideline compliantGLP testing | B′SYS specially trained study directors provide guideline compliant
Safety services | B′SYS performs tests to identify drug interactions with cardiac ion channels that act as target for QT prolongation.
Central nervous safety tests involve targets that are involved in addiction and neurotoxicity. Learn more
on of dose solutions. Standardized procedures lead to precise data and rapid study accomplishment.
Discovery services | Ion channel subtype selectivity is assessed using the B′SYS
panel of ion channel subsets providing the basis for selectivity screens.
The important issue of ion channel state dependency is particularly important in assessing effects on sodium- and calcium channels: the theon of dose solutions. Standardized procedures lead to precise data and rapid study accomplishment.
To simulate a more physiological situation, we assessed if ion channel assays using the patch-clamp technique can be performed in the presence of human plasma.
To investigate the effect of plasma binding of test compounds on the IC50 value for two compounds the dose response curve was determined in presence of standard bath solution and in the presence of human plasma.the basis for risk assessment. If assays The important issue of ion channel state dependency is particularly important in assessing effects on sodium- and calcium channels: the theon of dose solutions. Standardized procedures lead to precise data and rapid study accomplishment.
