Cell Lines

Stable cell line generation

Ligand gated ion channels

Acetylcholine

Target Gene Species Disorder Cell Type Expression    
nAChR α4β2 CHRNA4 / CHRNB2 human Cognition CHO constitutive

GABAA

Target Gene Species Disorder Cell Type Expression    
GABAA α1β2γ2 GABRA1 / GABRB2 / GABRG2 human Psychiatric Disorders CHO constitutive
GABAA α2β2γ2 GABRA2 / GABRB2 / GABRG2 human Psychiatric Disorders HEK 293 inducible

Glutamate

Target Gene Species Disorder Cell Type Expression    
Kainate K2 GRIK2 human Epilepsy CHO constitutive
Kainate K2 GRIK2 human Epilepsy HEK 293 inducible
NMDAR1 GRIN1 human Mental retardation HEK 293 inducible
NMDA (NR1 / 2A) GRIN1 / GRIN2A human Epilepsy / Psychiatric Disorders HEK 293 inducible
NMDA (NR1 / 2B) GRIN1 / GRIN2B human Depression HEK 293 inducible
NMDA (NR1 / 2D) GRIN1 / GRIN2D human Seizure disorders HEK 293 inducible

Glycine

Target Gene Species Disorder Cell Type Expression    
GlyRα1 GLRA1 human Pain sensation CHO constitutive
GlyRα2 GLRA2 human Epilepsy CHO constitutive
GlyRα3 GLRA3 human Pain sensation HEK 293 inducible
GlyRα3 GLRA3 rat Pain sensation CHO constitutive
GlyRα3 GLRA3 human Pain sensation CHO constitutive

Serotonin

Target Gene Species Disorder Cell Type Expression    
5HT3A 5HT3A human Psychiatric Disorders CHO constitutive

Acid Sensing

Target Gene Species Disorder Cell Type Expression    
ASIC1a long ACCN2 human Pain CHO constitutive
ASIC1a short ACCN2 human Pain CHO constitutive
ASIC1b ACCN2 human Pain CHO constitutive
ASIC2 ACCN1 human Epilepsy / Migraine / Pain CHO constitutive

P2X

Target Gene Species Disorder Cell Type Expression    
P2X1 P2rx1 human Immune system related CHO constitutive
P2X2 P2rx2 human CHO constitutive
P2X2/3 P2rx2/P2rx3 human Pain CHO constitutive
P2X3 P2rx3 human Pain CHO constitutive
P2X4 P2rx4 human Immune system related HEK 293 constitutive
P2X7 P2rx7 human Neuroinflammation HEK 293 constitutive

Voltage gated ion channels (VGIC)

Potassium

Target Gene Species Disorder Cell Type Expression    
KV1.1 KCNA1 human Seizure disorders CHO constitutive
KV1.2 KCNA2 human Seizure disorders CHO constitutive
KV1.3 KCNA3 human Immune system related CHO constitutive
KV1.4 KCNA4 human Autoimmune diseases CHO constitutive
KV1.5 KCNA5 human Heart function CHO constitutive
KV1.6 KCNA6 human Seizure disorders CHO constitutive
KV1.7 KCNA7 human Heart function CHO constitutive
KV2.1 KCNB1 human Seizure disorders CHO constitutive
KV2.1 KCNB1 human Seizure disorders HEK 293 inducible
KV2.2 KCNB2 human Seizure disorders CHO constitutive
KV2.2 KCNB2 human Seizure disorders HEK 293 inducible
KV3.1a (short) KCNC1 human Autism / Epilepsy / Pain / Psychiatric Disorders CHO constitutive
KV3.1b (long) KCNC1 human Autism / Epilepsy / Pain / Psychiatric Disorders CHO constitutive
KV3.2 KCNC2 human Epilepsy / Pain / Psychiatric Disorders CHO inducible
KV3.3 KCNC3 human Hearing disorders / Spinocerebellar ataxia CHO constitutive
KV3.4 KCNC4 human Neurodegeneration CHO inducible
KV4.2 KCND2 human Seizure disorders CHO constitutive
KV4.3 KCND3 human Heart function CHO constitutive
KV4.3 KCND3 human Heart function HEK 293 inducible
KV4.3 KChip KCND3 human Heart function CHO constitutive
KV7.1 (KVLQT1) / minK KCNQ1 / KCNE1 human LQT Syndrome HEK 293 constitutive
KV7.1 (KVLQT1) KCNQ1 human LQT Syndrome CHO constitutive
KV7.1 (KVLQT1) KCNQ1 human LQT Syndrome HEK 293 inducible
KV7.1 (KVLQT1) KCNQ1 human LQT Syndrome 1/5 HEK 293 constitutive
KV7.1 (KVLQT1) / minK KCNQ1/KCNE1 human LQT Syndrome 1/5 HEK 293 constitutive
KV7.1 (KVLQT1) / minK KCNQ1/KCNE1 human LQT Syndrome 1/5 CHO constitutive
KV7.2 KCNQ2 human Epilepsy CHO constitutive
KV7.3 KCNQ3 human Epilepsy CHO constitutive
KV7.2/3 KCNQ2 / KCNQ3 rat Epilepsy CHO constitutive
KV7.2/3 KCNQ2 / KCNQ3 human Epilepsy CHO constitutive
KV10.1 KCNH1 human Cancer CHO constitutive
KV11.1 (hERG DUO) KCNH2 human LQT Syndrome 2 CHO constitutive
KV11.1 (hERG) KCNH2 human LQT Syndrome 2 CHO constitutive
KV11.1 (hERG) KCNH2 human LQT Syndrome 2 CHO inducible
KV11.1 (hERG) KCNH2 human LQT Syndrome 2 HEK 293 constitutive
KV11.1 (hERG) KCNH2 human LQT Syndrome 2 HEK 293 inducible
Kir1.1 KCNJ1 human CHO constitutive
Kir2.1 KCNJ2 human LQT Syndrome CHO constitutive
Kir2.3 KCNJ4 human LQT Syndrome 9 HEK 293 constitutive
Kir2.3 KCNJ4 human LQT Syndrome 9 CHO constitutive
BK α1 KCNMA1 human Epilepsy / Pain CHO constitutive
BK α1 KCNMA1 human Epilepsy / Pain HEK 293 inducible
BK α1β2 KCNMA1 / KCNMB2 human Autism / Seizure disorders CHO inducible
BK α1β4 KCNMA1 / KCNMB4 human Seizure disorders CHO inducible
SK2, KCa2.2 KCNN2 human Heart function / Seizure disorders CHO inducible
SK1 / SK2, KCa2.1 / KCa2.2 KCNN1 / KCNN2 human CHO inducible
SK4, KCa3.1 KCNN4 human Heart function CHO constitutive
K2P18.1 KCNK18 human Pain HEK 293 constitutive
KCa4.1 KCNT1 human Seizure disorders CHO inducible

HCN

Target Gene Species Disorder Cell Type Expression    
HCN1 HCN1 human Epilepsy HEK 293 inducible
HCN2 HCN2 rat Cognition / Epilepsy / Heart function HEK 293 inducible
HCN2 HCN2 human Cognition / Epilepsy / Heart function HEK 293 inducible
HCN3 HCN3 human Heart function HEK 293 inducible
HCN4 HCN4 rat Heart function HEK 293 inducible
HCN4 HCN4 human Heart function HEK 293 inducible

Sodium

Target Gene Species Disorder Cell Type Expression    
NaV1.1 SCN1A human Epilepsy CHO constitutive
NaV1.2 SCN2A human Autism / Epilepsy / Intellectual disability CHO constitutive
NaV1.3 SCN3A human Epilepsy / Pain CHO constitutive
NaV1.4 SCN4A human Myotonia HEK 293 inducible
NaV1.4 SCN4A human Myotonia CHO constitutive
NaV1.5 SCN5A human LQT Syndrome 3 HEK inducible
NaV1.5 SCN5A human LQT Syndrome 3 HEK constitutive
NaV1.5 duo SCN5A human LQT Syndrome 3 CHO constitutive
NaV1.5 big late SCN5A L409C/A410W human LQT Syndrome 3 HEK 293 constitutive
NaV1.5 ΔKPQ SCN5A ΔKPQ human LQT Syndrome 3 HEK constitutive
NaV1.6 SCN8A human Epilepsy / Intellectual disability CHO constitutive
NaV1.7 SCN9A human Pain CHO constitutive
NaV1.7 SCN9A human Pain CHO inducible
NaV1.8 SCN10A/SCN3B human Neuropathy CHO constitutive
NaV1.9 SCN11A human Pain HEK inducible

Calcium

Target Gene Species Disorder Cell Type Expression    
CaV1.2 CACNA1C/CACNB2/ CACNA2D human Autism / Heart function / Psychiatric Disorders HEK 293 inducible
CaV3.1 CACNA1G human Cognition CHO constitutive
CaV3.2 CACNA1H human Epilepsy / Pain HEK 293 constitutive
CaV3.3 CACNA1I human HEK constitutive
CaV3.3 CACNA1I human CHO inducible

Chloride

Target Gene Species Disorder Cell Type Expression    
CFTR CFTR human Cystic fibrosis CHO constitutive
ClC-1 CLCN1 human Myotonia HEK 293 inducible
ClC-1 CLCN1 human Myotonia CHO constitutive

TRP

Target Gene Species Disorder Cell Type Expression    
TRPA1 TRPA1 human Itch / Pain CHO constitutive
TRPM1 TRPM1 human CHO inducible
TRPM2 TRPM2 human Depression / Ischemia / Psychiatric Disorders CHO inducible
TRPM4 TRPM4 human Heart function / Stroke CHO constitutive
TRPM5 TRPM5 human CHO inducible
TRPM8 TRPM8 human Pain sensation HEK 293 inducible
TRPV1 TRPV1 mouse Neuroinflammation / Pain / Psychiatric Disorders CHO constitutive
TRPV1 TRPV1 human Neuroinflammation / Pain / Psychiatric Disorders CHO constitutive
TRPV3 TRPV3 mouse Olmsted syndrom CHO constitutive
TRPV3 TRPV3 human Olmsted syndrom CHO constitutive
TRPV4 TRPV4 mouse Dwarfism, Neuropathy CHO constitutive
TRPV4 TRPV4 human Dwarfism, Neuropathy HEK 293 inducible