| Target | Gene | Species | Disorder | Cell Type | Expression | ||
|---|---|---|---|---|---|---|---|
| nAChR α4β2 | CHRNA4 / CHRNB2 | human | Cognition | CHO | constitutive |
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| Target | Gene | Species | Disorder | Cell Type | Expression | ||
|---|---|---|---|---|---|---|---|
| GABAA α1β2γ2 | GABRA1 / GABRB2 / GABRG2 | human | Psychiatric Disorders | CHO | constitutive |
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| GABAA α2β2γ2 | GABRA2 / GABRB2 / GABRG2 | human | Psychiatric Disorders | HEK 293 | inducible | |
| Target | Gene | Species | Disorder | Cell Type | Expression | ||
|---|---|---|---|---|---|---|---|
| Kainate K2 | GRIK2 | human | Epilepsy | CHO | constitutive | |
|
| Kainate K2 | GRIK2 | human | Epilepsy | HEK 293 | inducible |
|
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| NMDAR1 | GRIN1 | human | Mental retardation | HEK 293 | inducible |
|
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| NMDA (NR1 / 2A) | GRIN1 / GRIN2A | human | Epilepsy / Psychiatric Disorders | HEK 293 | inducible |
|
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| NMDA (NR1 / 2B) | GRIN1 / GRIN2B | human | Depression | HEK 293 | inducible |
|
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| NMDA (NR1 / 2D) | GRIN1 / GRIN2D | human | Seizure disorders | HEK 293 | inducible |
|
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| Target | Gene | Species | Disorder | Cell Type | Expression | ||
|---|---|---|---|---|---|---|---|
| GlyRα1 | GLRA1 | human | Pain sensation | CHO | constitutive |
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| GlyRα2 | GLRA2 | human | Epilepsy | CHO | constitutive |
|
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| GlyRα3 | GLRA3 | human | Pain sensation | HEK 293 | inducible | |
|
| GlyRα3 | GLRA3 | rat | Pain sensation | CHO | constitutive | |
|
| GlyRα3 | GLRA3 | human | Pain sensation | CHO | constitutive |
|
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| Target | Gene | Species | Disorder | Cell Type | Expression | ||
|---|---|---|---|---|---|---|---|
| 5HT3A | 5HT3A | human | Psychiatric Disorders | CHO | constitutive | |
| Target | Gene | Species | Disorder | Cell Type | Expression | ||
|---|---|---|---|---|---|---|---|
| ASIC1a long | ACCN2 | human | Pain | CHO | constitutive | |
|
| ASIC1a short | ACCN2 | human | Pain | CHO | constitutive | |
|
| ASIC1b | ACCN2 | human | Pain | CHO | constitutive | |
|
| ASIC2 | ACCN1 | human | Epilepsy / Migraine / Pain | CHO | constitutive | |
| Target | Gene | Species | Disorder | Cell Type | Expression | ||
|---|---|---|---|---|---|---|---|
| P2X1 | P2rx1 | human | Immune system related | CHO | constitutive |
|
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| P2X2 | P2rx2 | human | CHO | constitutive |
|
|
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| P2X2/3 | P2rx2/P2rx3 | human | Pain | CHO | constitutive |
|
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| P2X3 | P2rx3 | human | Pain | CHO | constitutive |
|
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| P2X4 | P2rx4 | human | Immune system related | HEK 293 | constitutive |
|
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| P2X7 | P2rx7 | human | Neuroinflammation | HEK 293 | constitutive |
|
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| Target | Gene | Species | Disorder | Cell Type | Expression | ||
|---|---|---|---|---|---|---|---|
| KV1.1 | KCNA1 | human | Seizure disorders | CHO | constitutive |
|
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| KV1.2 | KCNA2 | human | Seizure disorders | CHO | constitutive |
|
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| KV1.3 | KCNA3 | human | Immune system related | CHO | constitutive |
|
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| KV1.4 | KCNA4 | human | Autoimmune diseases | CHO | constitutive | |
|
| KV1.5 | KCNA5 | human | Heart function | CHO | constitutive |
|
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| KV1.6 | KCNA6 | human | Seizure disorders | CHO | constitutive | |
|
| KV1.7 | KCNA7 | human | Heart function | CHO | constitutive | |
|
| KV2.1 | KCNB1 | human | Seizure disorders | CHO | constitutive |
|
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| KV2.1 | KCNB1 | human | Seizure disorders | HEK 293 | inducible |
|
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| KV2.2 | KCNB2 | human | Seizure disorders | CHO | constitutive | |
|
| KV2.2 | KCNB2 | human | Seizure disorders | HEK 293 | inducible | |
|
| KV3.1a (short) | KCNC1 | human | Autism / Epilepsy / Pain / Psychiatric Disorders | CHO | constitutive | |
|
| KV3.1b (long) | KCNC1 | human | Autism / Epilepsy / Pain / Psychiatric Disorders | CHO | constitutive | |
|
| KV3.2 | KCNC2 | human | Epilepsy / Pain / Psychiatric Disorders | CHO | inducible | |
|
| KV3.3 | KCNC3 | human | Hearing disorders / Spinocerebellar ataxia | CHO | constitutive | |
|
| KV3.4 | KCNC4 | human | Neurodegeneration | CHO | inducible | |
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| KV4.2 | KCND2 | human | Seizure disorders | CHO | constitutive | |
|
| KV4.3 | KCND3 | human | Heart function | CHO | constitutive | |
|
| KV4.3 | KCND3 | human | Heart function | HEK 293 | inducible | |
|
| KV4.3 KChip | KCND3 | human | Heart function | CHO | constitutive | |
|
| KV7.1 (KVLQT1) / minK | KCNQ1 / KCNE1 | human | LQT Syndrome | HEK 293 | constitutive | |
|
| KV7.1 (KVLQT1) | KCNQ1 | human | LQT Syndrome | CHO | constitutive | |
|
| KV7.1 (KVLQT1) | KCNQ1 | human | LQT Syndrome | HEK 293 | inducible | |
|
| KV7.1 (KVLQT1) | KCNQ1 | human | LQT Syndrome 1/5 | HEK 293 | constitutive | |
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| KV7.1 (KVLQT1) / minK | KCNQ1/KCNE1 | human | LQT Syndrome 1/5 | HEK 293 | constitutive |
|
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| KV7.1 (KVLQT1) / minK | KCNQ1/KCNE1 | human | LQT Syndrome 1/5 | CHO | constitutive |
|
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| KV7.2 | KCNQ2 | human | Epilepsy | CHO | constitutive |
|
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| KV7.3 | KCNQ3 | human | Epilepsy | CHO | constitutive | |
|
| KV7.2/3 | KCNQ2 / KCNQ3 | rat | Epilepsy | CHO | constitutive | |
|
| KV7.2/3 | KCNQ2 / KCNQ3 | human | Epilepsy | CHO | constitutive | |
|
| KV10.1 | KCNH1 | human | Cancer | CHO | constitutive |
|
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| KV11.1 (hERG DUO) | KCNH2 | human | LQT Syndrome 2 | CHO | constitutive |
|
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| KV11.1 (hERG) | KCNH2 | human | LQT Syndrome 2 | CHO | constitutive | |
|
| KV11.1 (hERG) | KCNH2 | human | LQT Syndrome 2 | CHO | inducible | |
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| KV11.1 (hERG) | KCNH2 | human | LQT Syndrome 2 | HEK 293 | constitutive | |
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| KV11.1 (hERG) | KCNH2 | human | LQT Syndrome 2 | HEK 293 | inducible | |
|
| Kir1.1 | KCNJ1 | human | CHO | constitutive | |
||
| Kir2.1 | KCNJ2 | human | LQT Syndrome | CHO | constitutive | |
|
| Kir2.3 | KCNJ4 | human | LQT Syndrome 9 | HEK 293 | constitutive | |
|
| Kir2.3 | KCNJ4 | human | LQT Syndrome 9 | CHO | constitutive | |
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| BK α1 | KCNMA1 | human | Epilepsy / Pain | CHO | constitutive | |
|
| BK α1 | KCNMA1 | human | Epilepsy / Pain | HEK 293 | inducible | |
|
| BK α1β2 | KCNMA1 / KCNMB2 | human | Autism / Seizure disorders | CHO | inducible |
|
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| BK α1β4 | KCNMA1 / KCNMB4 | human | Seizure disorders | CHO | inducible | |
|
| SK2, KCa2.2 | KCNN2 | human | Heart function / Seizure disorders | CHO | inducible |
|
|
| SK1 / SK2, KCa2.1 / KCa2.2 | KCNN1 / KCNN2 | human | CHO | inducible | |
||
| SK4, KCa3.1 | KCNN4 | human | Heart function | CHO | constitutive |
|
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| K2P18.1 | KCNK18 | human | Pain | HEK 293 | constitutive |
|
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| KCa4.1 | KCNT1 | human | Seizure disorders | CHO | inducible | |
| Target | Gene | Species | Disorder | Cell Type | Expression | ||
|---|---|---|---|---|---|---|---|
| HCN1 | HCN1 | human | Epilepsy | HEK 293 | inducible |
|
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| HCN2 | HCN2 | rat | Cognition / Epilepsy / Heart function | HEK 293 | inducible |
|
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| HCN2 | HCN2 | human | Cognition / Epilepsy / Heart function | HEK 293 | inducible |
|
|
| HCN3 | HCN3 | human | Heart function | HEK 293 | inducible | |
|
| HCN4 | HCN4 | rat | Heart function | HEK 293 | inducible |
|
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| HCN4 | HCN4 | human | Heart function | HEK 293 | inducible |
|
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| Target | Gene | Species | Disorder | Cell Type | Expression | ||
|---|---|---|---|---|---|---|---|
| NaV1.1 | SCN1A | human | Epilepsy | CHO | constitutive | |
|
| NaV1.2 | SCN2A | human | Autism / Epilepsy / Intellectual disability | CHO | constitutive |
|
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| NaV1.3 | SCN3A | human | Epilepsy / Pain | CHO | constitutive | |
|
| NaV1.4 | SCN4A | human | Myotonia | HEK 293 | inducible |
|
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| NaV1.4 | SCN4A | human | Myotonia | CHO | constitutive |
|
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| NaV1.5 | SCN5A | human | LQT Syndrome 3 | HEK | inducible | |
|
| NaV1.5 | SCN5A | human | LQT Syndrome 3 | HEK | constitutive | |
|
| NaV1.5 duo | SCN5A | human | LQT Syndrome 3 | CHO | constitutive |
|
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| NaV1.5 big late | SCN5A L409C/A410W | human | LQT Syndrome 3 | HEK 293 | constitutive |
|
|
| NaV1.5 ΔKPQ | SCN5A ΔKPQ | human | LQT Syndrome 3 | HEK | constitutive | |
|
| NaV1.6 | SCN8A | human | Epilepsy / Intellectual disability | CHO | constitutive | |
|
| NaV1.7 | SCN9A | human | Pain | CHO | constitutive |
|
|
| NaV1.7 | SCN9A | human | Pain | CHO | inducible |
|
|
| NaV1.8 | SCN10A/SCN3B | human | Neuropathy | CHO | constitutive |
|
|
| NaV1.9 | SCN11A | human | Pain | HEK | inducible |
|
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| Target | Gene | Species | Disorder | Cell Type | Expression | ||
|---|---|---|---|---|---|---|---|
| CaV1.2 | CACNA1C/CACNB2/ CACNA2D | human | Autism / Heart function / Psychiatric Disorders | HEK 293 | inducible |
|
|
| CaV3.1 | CACNA1G | human | Cognition | CHO | constitutive |
|
|
| CaV3.2 | CACNA1H | human | Epilepsy / Pain | HEK 293 | constitutive | |
|
| CaV3.3 | CACNA1I | human | HEK | constitutive | |
||
| CaV3.3 | CACNA1I | human | CHO | inducible | |
| Target | Gene | Species | Disorder | Cell Type | Expression | ||
|---|---|---|---|---|---|---|---|
| CFTR | CFTR | human | Cystic fibrosis | CHO | constitutive | |
|
| ClC-1 | CLCN1 | human | Myotonia | HEK 293 | inducible | |
|
| ClC-1 | CLCN1 | human | Myotonia | CHO | constitutive | |
| Target | Gene | Species | Disorder | Cell Type | Expression | ||
|---|---|---|---|---|---|---|---|
| TRPA1 | TRPA1 | human | Itch / Pain | CHO | constitutive |
|
|
| TRPM1 | TRPM1 | human | CHO | inducible | |
||
| TRPM2 | TRPM2 | human | Depression / Ischemia / Psychiatric Disorders | CHO | inducible | |
|
| TRPM4 | TRPM4 | human | Heart function / Stroke | CHO | constitutive | |
|
| TRPM5 | TRPM5 | human | CHO | inducible | |
||
| TRPM8 | TRPM8 | human | Pain sensation | HEK 293 | inducible |
|
|
| TRPV1 | TRPV1 | mouse | Neuroinflammation / Pain / Psychiatric Disorders | CHO | constitutive | |
|
| TRPV1 | TRPV1 | human | Neuroinflammation / Pain / Psychiatric Disorders | CHO | constitutive | |
|
| TRPV3 | TRPV3 | mouse | Olmsted syndrom | CHO | constitutive | |
|
| TRPV3 | TRPV3 | human | Olmsted syndrom | CHO | constitutive |
|
|
| TRPV4 | TRPV4 | mouse | Dwarfism, Neuropathy | CHO | constitutive | |
|
| TRPV4 | TRPV4 | human | Dwarfism, Neuropathy | HEK 293 | inducible |
|
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