Safety services
B'SYS performs tests to identify drug interactions with cardiac ion channels that act as target for QT prolongation.

Central nervous safety tests involve targets that are involved in addiction and neurotoxicity. B'SYS conducts assays to determine single concentration activities or concentration response relationships of test compounds.

  • Cardiac ion channel panel for identification and assessment of drugs that alter the QT interval
  • Cardiomyocyte action potential assays
  • Central nervous system panel for the identification of sedative, addictive or neurotoxic potential of test compounds.
  • Cardiotoxicity Screening (MEA, impedance)

Catalog

Cardiac Panel

Target Gene Species Disorder Manual Automated    
CaV1.2 CACNA1C/CACNB2/ CACNA2D human Autism / Heart function / Psychiatric Disorders 0 0
CaV3.2 CACNA1H human Epilepsy / Pain 0 0
NaV1.5 SCN5A human LQT Syndrome 3 0 0
NaV1.5 / late current SCN5A human LQT Syndrome 3 0 0
KV11.1 (hERG) KCNH2 human LQT Syndrome 2 0 0
KV1.5 KCNA5 human Heart function 0 0
KV4.3 KChip KCND3 human Heart function 0 0
KV7.1 (KVLQT1) / minK KCNQ1/KCNE1 human LQT Syndrome 1/5 0 0
Kir2.1 KCNJ2 human LQT Syndrome 0 0

CNS Panel

Target Gene Species Disorder Manual Automated    
KV7.2 KCNQ2 human Epilepsy 0 1
KV7.2/3 KCNQ2 / KCNQ3 human Epilepsy 0 0
NaV1.1 SCN1A human Epilepsy 0 0
NaV1.2 SCN2A human Autism / Epilepsy / Intellectual disability 0 0
NaV1.3 SCN3A human Epilepsy / Pain 0 0
NaV1.6 SCN8A human Epilepsy / Intellectual disability 0 0
NaV1.7 SCN9A human Pain 0 0
NaV1.8 SCN10A/SCN3B human Neuropathy 0 0
Neuroblastoma whole sodium (TTX sensitive sodium channels) 0 0
CaV2.1 CACNA1A / CACNB3 / CACNA2D2 or CACNA2D4 human Ataxia / Epilepsy / Migraine 0 1
ClC-2 CLCN2 human 0 1
GABAA α1β2γ2 GABRA1 / GABRB2 / GABRG2 human Psychiatric Disorders 0 0
GABAA α1β3γ2 GABRA1 / GABRB3 / GABRG2 human 0 0
GABAA α2β2γ2 GABRA2 / GABRB2 / GABRG2 human Psychiatric Disorders 0 0
GABAA α3β2γ2 GABRA3 / GABRB2 / GABRG2 human 0 0
GABAA α4β3δ GABRA4 / GABRB3 / GABRD human Depression / Psychiatric Disorders 0 1
GABAA α5β2γ2 GABRA5 / GABRB2 / GABRG2 human Cognition 0 0
GABAA α6β3δ GABRA6 / GABRB3 / GABRD human Depression / Psychiatric Disorders 0 1
GlyRα3 GLRA3 human Pain sensation 0 1
nAChR α4β2 CHRNA4 / CHRNB2 human Cognition 0 0
nAChR α7 CHRNA7 human Cognition / Psychiatric Disorders 0 1
5HT3A 5HT3A human Psychiatric Disorders 0 0
P2X7 P2rx7 human Neuroinflammation 0 0
AMPA GRIA1 human Cognition / Psychiatric Disorders 0 1
Kainate K2 GRIK2 human Epilepsy 0 0
Kainate K2/K5 GRIK2 / GRIK5 human 0 1
NMDA (NR1 / 2A) GRIN1 / GRIN2A human Epilepsy / Psychiatric Disorders 0 0
NMDA (NR1 / 2B) GRIN1 / GRIN2B human Depression 0 0
NMDA (NR1 / 2C) GRIN1 / GRIN2C human 0 1
NMDA (NR1 / 2D) GRIN1 / GRIN2D human Seizure disorders 0 1

Memory Panel

Target Gene Species Disorder Manual Automated    
GABAA α5β2γ2 GABRA5 / GABRB2 / GABRG2 human Cognition 0 0
AMPA GRIA1 human Cognition / Psychiatric Disorders 0 1
nAChR α4β2 CHRNA4 / CHRNB2 human Cognition 0 0
nAChR α7 CHRNA7 human Cognition / Psychiatric Disorders 0 1
NMDA (NR1 / 2A) GRIN1 / GRIN2A human Epilepsy / Psychiatric Disorders 0 0
NMDA (NR1 / 2B) GRIN1 / GRIN2B human Depression 0 0

Antiepileptic Panel

Target Gene Species Disorder Manual Automated    
KV7.2/3 KCNQ2 / KCNQ3 human Epilepsy 0 0
KV7.2 KCNQ2 human Epilepsy 0 1
NaV1.1 SCN1A human Epilepsy 0 0
NaV1.2 SCN2A human Autism / Epilepsy / Intellectual disability 0 0
NaV1.3 SCN3A human Epilepsy / Pain 0 0
NaV1.6 SCN8A human Epilepsy / Intellectual disability 0 0
NaV1.7 SCN9A human Pain 0 0
NaV1.8 SCN10A/SCN3B human Neuropathy 0 0
Neuroblastoma whole sodium (TTX sensitive sodium channels) 0 0
CaV2.1 CACNA1A / CACNB3 / CACNA2D2 or CACNA2D4 human Ataxia / Epilepsy / Migraine 0 1
ClC-2 CLCN2 human 0 1
GABAA α1β2γ2 GABRA1 / GABRB2 / GABRG2 human Psychiatric Disorders 0 0
GABAA α1β3γ2 GABRA1 / GABRB3 / GABRG2 human 0 0
GABAA α2β2γ2 GABRA2 / GABRB2 / GABRG2 human Psychiatric Disorders 0 0
GABAA α3β2γ2 GABRA3 / GABRB2 / GABRG2 human 0 0
GABAA α4β3δ GABRA4 / GABRB3 / GABRD human Depression / Psychiatric Disorders 0 1
GABAA α5β2γ2 GABRA5 / GABRB2 / GABRG2 human Cognition 0 0
GABAA α6β3δ GABRA6 / GABRB3 / GABRD human Depression / Psychiatric Disorders 0 1
GlyRα3 GLRA3 human Pain sensation 0 0
AMPA GRIA1 human Cognition / Psychiatric Disorders 0 1
NMDA (NR1 / 2A) GRIN1 / GRIN2A human Epilepsy / Psychiatric Disorders 0 0
NMDA (NR1 / 2B) GRIN1 / GRIN2B human Depression 0 0

Pain Panel

Target Gene Species Disorder Manual Automated    
NaV1.7 SCN9A human Pain 0 0
NaV1.8 SCN10A/SCN3B human Neuropathy 0 0
GABAA α1β2γ2 GABRA1 / GABRB2 / GABRG2 human Psychiatric Disorders 0 0
GABAA α1β3γ2 GABRA1 / GABRB3 / GABRG2 human 0 0
GABAA α2β2γ2 GABRA2 / GABRB2 / GABRG2 human Psychiatric Disorders 0 0
GABAA α3β2γ2 GABRA3 / GABRB2 / GABRG2 human 0 0
GABAA α4β3δ GABRA4 / GABRB3 / GABRD human Depression / Psychiatric Disorders 0 1
GABAA α5β2γ2 GABRA5 / GABRB2 / GABRG2 human Cognition 0 0
GABAA α6β3δ GABRA6 / GABRB3 / GABRD human Depression / Psychiatric Disorders 0 1
GlyRα3 GLRA3 human Pain sensation 0 0
AMPA GRIA1 human Cognition / Psychiatric Disorders 0 1
TRPV1 TRPV1 human Neuroinflammation / Pain / Psychiatric Disorders 0 0
TRPV2 TRPV2 human 0 1
NMDA (NR1 / 2A) GRIN1 / GRIN2A human Epilepsy / Psychiatric Disorders 0 0
NMDA (NR1 / 2B) GRIN1 / GRIN2B human Depression 0 0