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Ligand gated ion channels

Acetylcholine

Target Gene Species Disorder Manual Automated    
nAChR α3β4 CHRNA3 / CHRNB4 human Cognition 0 1
nAChR α4β2 CHRNA4 / CHRNB2 human Cognition 0 0
nAChR α7 CHRNA7 human Cognition / Psychiatric Disorders 0 1

GABAA

Target Gene Species Disorder Manual Automated    
GABAA α1β2γ2 GABRA1 / GABRB2 / GABRG2 human Psychiatric Disorders 0 0
GABAA α1β3γ2 GABRA1 / GABRB3 / GABRG2 human 0 0
GABAA α2β2γ2 GABRA2 / GABRB2 / GABRG2 human Psychiatric Disorders 0 0
GABAA α3β2γ2 GABRA3 / GABRB2 / GABRG2 human 0 0
GABAA α4β3δ GABRA4 / GABRB3 / GABRD human Depression / Psychiatric Disorders 0 1
GABAA α5β2γ2 GABRA5 / GABRB2 / GABRG2 human Cognition 0 0
GABAA α6β3δ GABRA6 / GABRB3 / GABRD human Depression / Psychiatric Disorders 0 1
GABAA (β3) GABRB3 human 0 0

Glutamate

Target Gene Species Disorder Manual Automated    
AMPA GRIA1 human Cognition / Psychiatric Disorders 0 1
Kainate K1 GRIK1 human Seizure disorders 0 1
Kainate K2 GRIK2 human Epilepsy 0 0
Kainate K2 GRIK2 human Epilepsy 0 0
Kainate K2/K5 GRIK2 / GRIK5 human 0 1
NMDA (NR1 / 2A) GRIN1 / GRIN2A human Epilepsy / Psychiatric Disorders 0 0
NMDA (NR1 / 2B) GRIN1 / GRIN2B human Depression 0 0
NMDA (NR1 / 2C) GRIN1 / GRIN2C human 0 1
NMDA (NR1 / 2D) GRIN1 / GRIN2D human Seizure disorders 0 1

Glycine

Target Gene Species Disorder Manual Automated    
GlyRα1 GLRA1 human Pain sensation 0 0
GlyRα2 GLRA2 human Epilepsy 0 1
GlyRα3 GLRA3 human Pain sensation 0 1
GlyRα3 GLRA3 rat Pain sensation 0 1
GlyRα3 GLRA3 human Pain sensation 0 0
GlyRα3β GLRA3 / GLRB human 0 1

Serotonin

Target Gene Species Disorder Manual Automated    
5HT3A 5HT3A human Psychiatric Disorders 0 0
5HT3A/B 5HT3A / 5HT3B human 0 1

Acid Sensing

Target Gene Species Disorder Manual Automated    
ASIC1a long ACCN2 human Pain 0 0
ASIC1a short ACCN2 human Pain 0 0
ASIC1b ACCN2 human Pain 0 0
ASIC2 ACCN1 human Epilepsy / Migraine / Pain 0 1
ASIC3 ACCN3 human Pain / Psoriasis 0 1

P2X

Target Gene Species Disorder Manual Automated    
P2X1 P2rx1 human Immune system related 0 1
P2X2 P2rx2 human 0 0
P2X2/3 P2rx2/P2rx3 human Pain 0 1
P2X3 P2rx3 human Pain 0 1
P2X4 P2rx4 human Immune system related 0 0
P2X7 P2rx7 human Neuroinflammation 0 0

Voltage gated ion channels (VGIC)

Potassium

Target Gene Species Disorder Manual Automated    
KV1.1 KCNA1 human Seizure disorders 0 0
KV1.2 KCNA2 human Seizure disorders 0 0
KV1.3 KCNA3 human Immune system related 0 0
KV1.4 KCNA4 human Autoimmune diseases 0 0
KV1.5 KCNA5 human Heart function 0 0
KV1.6 KCNA6 human Seizure disorders 0 0
KV1.7 KCNA7 human Heart function 0 0
KV2.1 KCNB1 human Seizure disorders 0 0
KV2.1 KCNB1 human Seizure disorders 0 0
KV2.2 KCNB2 human Seizure disorders 0 0
KV2.2 KCNB2 human Seizure disorders 0 0
KV3.1a (short) KCNC1 human Autism / Epilepsy / Pain / Psychiatric Disorders 0 0
KV3.1b (long) KCNC1 human Autism / Epilepsy / Pain / Psychiatric Disorders 0 0
KV3.2 KCNC2 human Epilepsy / Pain / Psychiatric Disorders 0 1
KV3.3 KCNC3 human Hearing disorders / Spinocerebellar ataxia 0 1
KV3.4 KCNC4 human Neurodegeneration 0 1
KV4.2 KCND2 human Seizure disorders 0 1
KV4.3 KCND3 human Heart function 0 0
KV4.3 KCND3 human Heart function 0 1
KV4.3 KChip KCND3 human Heart function 0 0
KV7.1 (KVLQT1) / minK KCNQ1 / KCNE1 human LQT Syndrome 0 0
KV7.1 (KVLQT1) KCNQ1 human LQT Syndrome 0 1
KV7.1 (KVLQT1) KCNQ1 human LQT Syndrome 0 1
KV7.1 (KVLQT1) KCNQ1 human LQT Syndrome 1/5 0 1
KV7.1 (KVLQT1) / minK KCNQ1/KCNE1 human LQT Syndrome 1/5 0 0
KV7.1 (KVLQT1) / minK KCNQ1/KCNE1 human LQT Syndrome 1/5 0 0
KV7.1 (KVLQT1) / minK / steady state current KCNQ1/KCNE1 human LQT Syndrome 1/5 0 1
KV7.2 KCNQ2 human Epilepsy 0 1
KV7.3 KCNQ3 human Epilepsy 0 1
KV7.2/3 KCNQ2 / KCNQ3 rat Epilepsy 0 0
KV7.2/3 KCNQ2 / KCNQ3 human Epilepsy 0 0
KV10.1 KCNH1 human Cancer 0 1
KV11.1 (hERG DUO) KCNH2 human LQT Syndrome 2 0 0
KV11.1 (hERG) / trafficking KCNH2 human LQT Syndrome 2 0 0
KV11.1 (hERG) / peak tail current KCNH2 human LQT Syndrome 2 0 1
KV11.1 (hERG) KCNH2 human LQT Syndrome 2 0 0
KV11.1 (hERG) KCNH2 human LQT Syndrome 2 0 0
KV11.1 (hERG) KCNH2 human LQT Syndrome 2 0 0
KV11.1 (hERG) KCNH2 human LQT Syndrome 2 0 0
Kir1.1 KCNJ1 human 0 0
Kir2.1 KCNJ2 human LQT Syndrome 0 0
Kir2.3 KCNJ4 human LQT Syndrome 9 0 1
Kir2.3 KCNJ4 human LQT Syndrome 9 0 1
Kir3.1 KCNJ3 human 0 1
Kir3.4 KCNJ5 human 0 1
BK α1 KCNMA1 human Epilepsy / Pain 0 0
BK α1β2 KCNMA1 / KCNMB2 human Autism / Seizure disorders 0 0
SK1, KCa2.1 KCNN1 human 0 1
SK2, KCa2.2 KCNN2 human Heart function / Seizure disorders 0 1
SK4, KCa3.1 KCNN4 human Heart function 0 1
K2P18.1 KCNK18 human Pain 0 0
KCa4.1 KCNT1 human Seizure disorders 0 1
K2P1.1 KCNK1 human 0 1
Neuroblastoma whole potassium channels (N1E-115) 0 1

HCN

Target Gene Species Disorder Manual Automated    
HCN1 HCN1 human Epilepsy 0 0
HCN2 HCN2 rat Cognition / Epilepsy / Heart function 0 0
HCN2 HCN2 human Cognition / Epilepsy / Heart function 0 0
HCN3 HCN3 human Heart function 0 1
HCN4 HCN4 rat Heart function 0 0
HCN4 HCN4 human Heart function 0 0

Sodium

Target Gene Species Disorder Manual Automated    
NaV1.1 SCN1A human Epilepsy 0 0
NaV1.2 SCN2A human Autism / Epilepsy / Intellectual disability 0 0
NaV1.3 SCN3A human Epilepsy / Pain 0 0
NaV1.4 SCN4A human Myotonia 0 0
NaV1.4 SCN4A human Myotonia 0 0
NaV1.5 SCN5A human LQT Syndrome 3 0 0
NaV1.5 SCN5A human LQT Syndrome 3 0 0
NaV1.5 / ATXII-activated late current SCN5A human LQT Syndrome 3 0 0
NaV1.5 / late current SCN5A human LQT Syndrome 3 0 0
NaV1.5 / peak current SCN5A human LQT Syndrome 3 0 0
NaV1.5 duo SCN5A human LQT Syndrome 3 0 0
NaV1.5 big late SCN5A L409C/A410W human LQT Syndrome 3 0 0
NaV1.5 ΔKPQ SCN5A ΔKPQ human LQT Syndrome 3 0 0
NaV1.6 SCN8A human Epilepsy / Intellectual disability 0 0
NaV1.7 SCN9A human Pain 0 0
NaV1.7 SCN9A human Pain 0 0
NaV1.8 SCN10A/SCN3B human Neuropathy 0 0
NaV1.9 SCN11A human Pain 0 0
Neuroblastoma whole sodium (TTX sensitive sodium channels) 0 0

Calcium

Target Gene Species Disorder Manual Automated    
CaV1.2 CACNA1C/CACNB2/ CACNA2D human Autism / Heart function / Psychiatric Disorders 0 0
CaV1.2 / peak current CACNA1C/CACNB2/ CACNA2D human Autism / Heart function / Psychiatric Disorders 0 1
CaV1.3 CACNA1D / CACNB3 / CACNA2D human 0 0
CaV2.1 CACNA1A / CACNB3 / CACNA2D2 or CACNA2D4 human Ataxia / Epilepsy / Migraine 0 1
CaV3.1 CACNA1G human Cognition 0 1
CaV3.2 CACNA1H human Epilepsy / Pain 0 0
CaV3.3 CACNA1I human 0 1
CaV3.3 CACNA1I human 0 1
Neuroblastoma whole calcium (T- and L- type) 0 0

Chloride

Target Gene Species Disorder Manual Automated    
CFTR CFTR human Cystic fibrosis 0 0
CFTR CFTR human Cystic fibrosis 0 0
ClC-2 CLCN2 human 0 1

TRP

Target Gene Species Disorder Manual Automated    
TRPA1 TRPA1 human Itch / Pain 0 1
TRPM1 TRPM1 human 0 1
TRPM2 TRPM2 human Depression / Ischemia / Psychiatric Disorders 0 1
TRPM4 TRPM4 human Heart function / Stroke 0 1
TRPM5 TRPM5 human 0 1
TRPM8 TRPM8 human Pain sensation 0 0
TRPV1 TRPV1 mouse Neuroinflammation / Pain / Psychiatric Disorders 0 1
TRPV1 TRPV1 human Neuroinflammation / Pain / Psychiatric Disorders 0 0
TRPV2 TRPV2 human 0 1
TRPV3 TRPV3 mouse Olmsted syndrom 0 1
TRPV3 TRPV3 human Olmsted syndrom 0 1
TRPV4 TRPV4 mouse Dwarfism, Neuropathy 0 1
TRPV4 TRPV4 human Dwarfism, Neuropathy 0 1