B’SYS has developed a CHO Kv7.2 cell line with constitutive expression of human Kv7.2 (KCNQ2; NP_004512) potassium channels. The Kv7.2 cDNA was cloned and stably transfected into CHO cells, and functional expression of the Kv7.2 channels was validated using manual and automated patch-clamp techniques, including QPatch™.

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Kv7.2 channels contribute to the M-current (IM), a low-threshold, non-inactivating potassium current that plays a crucial role in stabilizing the resting membrane potential in neurons. By activating at subthreshold membrane potentials, Kv7.2 acts as a physiological "brake" on neuronal excitability, preventing excessive firing of action potentials. This makes it an important modulator of neuronal signaling and excitability.

Disruption of Kv7.2 function is associated with increased neuronal excitability and has been linked to seizure disorders such as benign familial neonatal epilepsy (BFNE). Given its role in maintaining neuronal stability and preventing hyperexcitability, Kv7.2 represents a relevant target for the development of therapeutics aimed at treating epilepsy and other excitability-related disorders.